BIOPOLIS, S.L. isolates and selects microorganisms, as well as performing the relevant functional and technological validation tests. We also develop and validate functional ingredients for the food industry.
BIOPOLIS, S.L. provides services related to the search and evaluation of novel functional ingredients and probiotics.
To be competitive in the food industry, it is essential to validate new ingredients in a fast, reliable and cost-effective way. Therefore BIOPOLIS, S.L. has developed novel high-throughput screening models in vitro and in vivo, which enable us to screen and characterize the target compound and define its metabolic pathway.
We can validate functional ingredients with biological activity against health disorders such as:
Functional validation methods:
To evaluate enzyme inhibition involved in certain metabolic disorders such as:
To evaluate spoilage microorganisms and/or pathogen growth inhibition.
BIOPOLIS, S.L. has developed novel high-throughput screening models in vivo, which provide fast screening of the target compound and definition of its metabolic pathway.
S. cerevisiae is one of the most intensively studied eukaryotic model organisms in molecular and cell biology due to its ease of handling and because it shares the complex internal cell structure of plants and animals.
Caenorhabditis elegans (ver pdf)
C. elegans is a high-throughput model to study the functional effects of nutraceuticals and novel food ingredients as well as foods against certain disorders:
This in vivo model along with nutrigenomics defines compound functionalities and metabolic targets very accurately and quickly. Nutrigenomics is a new technology that provides insight into how functional ingredients modulate the gene expression regulating a specific metabolism. C. elegans is fed on the selected ingredient and then gene expression is analyzed to determine the nutrient-gene interaction or the metabolic target of this specific ingredient.
Murine models (rat/mouse)
Prior to clinical studies, assays in murine models are one of the most useful approaches in order to ensure functional food properties. Functional murine trials:
In this procedure, living cells or tissues taken from an organism are cultured to screen the biological activity of a specific compound to substitute or replace existing in vivo models.
A wide range of cell cultures can be employed, depending on the activity to be measured and customer needs.